The Basics of Genetics and DNA
Read, explain, and reason about DNA, genes, and inheritance without falling for the myths most courses teach.
This course is for members
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What you will learn about The Basics of Genetics and DNA
The 7-day sprint
- The Molecule and Its Four Letters. DNA is a two-stranded molecule whose four bases pair in a fixed way, so the order of those bases carries the information.
- From Thread to Chromosome. A cell packages very long DNA molecules with histone proteins into chromatin, and the packaged form of one DNA molecule is a chromosome.
- What a Gene Actually Is. A gene is a segment of DNA that holds instructions for building a particular protein or functional RNA molecule, and much of the rest of the DNA controls when genes are used.
- DNA to RNA to Protein. Cells read a gene by transcribing DNA into RNA and, for protein-coding genes, translating that RNA three bases at a time into a chain of amino acids.
- Alleles, Genotype, and Phenotype. Because you carry two copies of most genes, the pair of sequence variants you have is your genotype, and the observable result is your phenotype.
- How Traits Are Actually Inherited. Simple dominant and recessive patterns are real but rare, and most familiar human traits come from many genes plus environment.
- Reading Real Genetics Without Getting Lost. Genomics, reference genomes, and standardized names are the machinery that lets one person's finding be understood by everyone else.
The 80/20: the 6 concepts that matter most
- Complementary base pairing
- A gene encodes a protein or a functional RNA
- Transcription, translation, and the triplet code
- Two copies, two alleles, genotype versus phenotype
- Most traits are polygenic and environment sensitive
- Standard names and reference sequences
The core idea, explained like you are 5
The order of four chemical letters along a DNA molecule is information, and a cell copies that order to pass it on and reads it to build the molecules that do the work.
Then the quiz and the ladder
10 questions that correct you when you are wrong, and beginner, intermediate, advanced levels, each with a practical exercise.
Created Sep 13, 2026. No mistakes have been reported by learners.
Written from these sources
- Deoxyribonucleic Acid (DNA), genome.gov. day 1 DNA definition, bases, primer wording.
- Deoxyribonucleic Acid (DNA) Fact Sheet, genome.gov. day 1 history, packaging, unwinding for replication.
- A Brief Guide to Genomics, genome.gov. day 7 genomics vs genetics, alphabet analogy, sequencing.
- Help Me Understand Genetics Cells and DNA Reprinted from MedlinePlus Genetics, medlineplus.gov. day 2 chromosome counts, p and q arms, junk DNA correction.
- How do genes direct the production of proteins?: MedlinePlus Genetics, medlineplus.gov. day 4 central dogma and stop codons.
- 15.2: The Genetic Code - The Central Dogma- DNA Encodes RNA and RNA Encodes Protein - Biology LibreTexts, bio.libretexts.org. day 4 codon counts, degeneracy, selenocysteine and pyrrolysine.
- 15.1 The Genetic Code | TEKS Guide, teksguide.org. day 4 codon examples and nearly universal code.
- What Are Chromosomes?, learn.genetics.utah.edu. day 3 gene definition, genome size, histone packaging.
- How Genes Are Inherited - Learn Genetics Utah, learn.genetics.utah.edu. day 3 noncoding DNA and connected genes caveat.
- © 2018 University of Utah Updated July 6, 2018 1 Teacher Guide, teach.genetics.utah.edu. day 2 nucleosome and chromatin figures.
- Eukaryotic chromosome structure, en.wikipedia.org. day 2 nucleosome octamer, linker histone, beads on a string.
- The complete sequence of a human genome, ncbi.nlm.nih.gov. day 7 T2T-CHM13 completeness figures.
- The complete sequence of a human genome | Science, science.org. day 7 complete human genome sequence details.
- T2T CHM13 v2.0 now available in the Genome Browser, groups.google.com. day 7 companion assembly caveat, not hg39.
- T2T-CHM13 – the complete human genome sequence - BioTechniques, biotechniques.com. day 3 protein-coding gene count context.
- The first gapless, reference-quality, fully annotated genome from a Southern Han Chinese individual, ncbi.nlm.nih.gov. day 7 Han1 genome comparison.
- HGNC Guidelines | HUGO Gene Nomenclature Committee, genenames.org. day 7 HGNC symbol rules and italics convention.
- Frequently asked questions | HUGO Gene Nomenclature Committee, genenames.org. day 7 HGNC scope and fusion symbol format.
- Genenames.org: the HGNC and PGNC resources in 2026, ncbi.nlm.nih.gov. day 3 and day 7 HGNC counts and renaming example.
- HGVS Recommendations for the Description of Sequence Variants: 2016 Update - Dunnen - 2016 - Human Mutation - Wiley Online Library, onlinelibrary.wiley.com. day 5 HGVS variant nomenclature standard.
- HGVS recommendations: nomenclature for the description of sequence variants, hgvs.org. day 5 prefixes, format, mutation and polymorphism wording.
- General recommendations - Sequence Variant Nomenclature, archive.hgvs-nomenclature.org. day 5 and day 7 reference sequence rules.
- Is eye color determined by genetics?: MedlinePlus Genetics, medlineplus.gov. day 6 eye color genes and continuum.
- Myths of Human Genetics: Eye Color, udel.edu. day 6 blue eyes as structural color, myth debunk.
- The complexity of eye colour - Institute for Molecular Bioscience - University of Queensland, imb.uq.edu.au. day 6 persistence of the single-gene teaching myth.
- Misconception Monday: Gimme a B! Now Gimme a b! | National Center for Science Education, ncse.ngo. day 6 challenge design, hypothetical Punnett squares.
- Common Misconceptions - Genetics Generation, knowgenetics.org. day 6 polygenic traits and probability fallacy.
- Five Misconceptions in Genetics - Carolina Knowledge Center, knowledge.carolina.com. day 5 glossary rationale and trait complexity.
- How do different genes contribute to our traits like eye and skin color? - The Tech Interactive, thetech.org. day 6 eye color prediction limits.